![]() Among the hospitalized patients, 29.4% were infected by Alpha, while 70.6% were infected with other strains. ![]() Of all patients, 34.5% were infected by the Alpha variant, and 6.4% were hospitalized. Led by researchers from the Statens Serum Institut in Copenhagen, the second study involved 30,572 COVID-19 patients with at least 14 days of follow-up data for hospitalization, virus genome data, and a positive COVID-19 test from Jan 1 to Mar 24, 6.6% of whom were healthcare workers. "The higher overall mortality and rate of CCU admission associated with lineage B.1.1.7, combined with its known increased transmissibility, are likely to put health-care systems under additional stress." 42% higher risk of hospitalization "Although we observed a higher risk of severe outcomes (CCU admission and overall mortality) associated with lineage B.1.1.7, once a patient was in a condition severe enough to be admitted to CCU, their risk of dying was not different between lineages," the authors concluded. The researchers said that, combined with evidence of increased infectivity, the results highlight the importance of maintaining measures to control exposure to and infection with COVID-19. By the end of the study period, 68.9% of Alpha patients had been released from the CCU, versus 91.7% in the non-Alpha group. Severity of illness, as measured using the Acute Physiology and Chronic Health Evaluation II, tended to be reduced in Alpha-infected patients, but the proportion requiring mechanical ventilation in the first 24 hours of admission to the CCU was higher. The researchers found no evidence of a significant association between Alpha infection and ethnic group, sex, or age, but patients with Alpha infections were slightly younger and more likely to be in the lowest body mass index category than those infected by other strains. In the CCU group, aHR for death was 0.91 for those with Alpha infections, compared with those with infections caused by other strains. The Alpha variant was also associated with a doubled risk of requiring CCU admission (adjusted hazard ratio, 2.15), but the researchers note it was not linked to death or need for organ support in those receiving critical care. Of the 4,272 CCU patients, 62.8% were infected by Alpha, and 15.5% died in the hospital.Īfter adjusting for covariables, primary care patients infected with the Alpha strain were 65% more likely to die by 28 days than those infected by other coronavirus lineages. Of the 198,420-person primary care group, 59.4% were infected by Alpha, 0.4% were admitted to a critical care unit (CCU, similar to a US intensive care unit), and 0.4% died by 28 days. In the first study, a team led by University of Oxford researchers studied data on a primary care cohort and a critical care group, both of which were infected by the Alpha variant and tested positive for COVID-19 from November 2020 to January 2021. 65% higher odds of death in primary care group Infection with the Alpha (B117) SARS-CoV-2 variant may pose a heightened risk of poor COVID-19 outcomes, according to two observational studies from England and Denmark published yesterday in The Lancet Infectious Diseases.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |